Antibacterial Potential of Gompang Batu Plant Extract (Lobelia nummularia Lam) Against Skin Disorder-Causing Bacteria

Abstract

Skin disorders are common health problems that are often caused by bacterial infections such as
Staphylococcus epidermis and Propionibacterium acnes. This study aims to analyze the antibacterial
potential of n-hexane, ethyl acetate, and ethanol extracts of gompang batu (Lobelia nummularia Lam)
plants against bacteria that cause skin disorders. Extraction was carried out by maceration with
solvents of varying polarity. Antibacterial tests were carried out using the disc diffusion and
microdilution methods with six treatments (chloramphenicol, DMSO, 1.25%; 2.5%; 5% and 10%
extract). The results showed that the ethanol extract with a concentration of 10% had the most effective
antibacterial activity with an inhibition zone of 14.0 mm (P. acnes bacteria) and 13.8 mm (S. epidermis
bacteria). The MIC value of the extract ranged from 156.25 to 625 µg/mL and the MBC value of all
extracts> 2500 µg/mL indicated bactericidal properties. Gompang batu has the potential as a natural
antibacterial for skin infections. N-hexane extract contains steroids and tannins; ethyl acetate contains
alkaloids, flavonoids, steroids and tannins; ethanol contains alkaloids, flavonoids, terpenoids and
tannins.