Suspension Stability Ethanol Extract Of Frankincense Gum (Styrax Benzoin)

Nora Susanti, Yosia Gopas Oetama Manik, Jamalum Purba

Abstract


Sap is a very important commodity in the industrial pharmacy, perfumes and medicines contain abundant active compounds of frankincense making resin widely used. Extraction and solvation processes play an important role in the production of stable frankincense extract. One of the widely used preparations is suspension, which is an active compound that does not dissolve in water to become soluble. The purpose of this study was to determine the manufacture of a suspension of frankincense gum extract as an active pharmaceutical ingredient. The method used was precipitation using cosolvent, surfactant and agitation process at 1500 rpm at a temperature of 40oC. Various comparisons were analyzed for phytochemical screening, viscosity and pH. in the most stable formula to be tested, the size of the suspension particles found that frankincense extract was soluble in distilled water with an average particle size is 4.80205 μm. .


Keywords


Suspension Stabiliy Extract Frankincense Styrax Benzoin Phytochemical Surfactan Kosolven Particle Size

Full Text:

PDF

References


Agrawal, YK, and VishalR Patel. 2011. “Nanosuspension: An Approach to Enhance Solubility of Drugs.” Journal of Advanced Pharmaceutical Technology & Research 2(2):81. doi: 10.4103/2231-4040.82950.

Badiah, H. I., F. Seedeh, G. Supriyanto, and A. H. Zaidan. 2019. “Synthesis of Silver Nanoparticles and the Development in Analysis Method.” IOP Conference Series: Earth and Environmental Science 217(1):1–8. doi: 10.1088/1755-1315/217/1/012005.

Burger, Pauline, Alexandre Casale, Audrey Kerdudo, Thomas Michel, Rémi Laville, Francis Chagnaud, and Xavier Fernandez. 2016. “New Insights in the Chemical Composition of Benzoin Balsams.” Food Chemistry 210:613–22. doi: 10.1016/j.foodchem.2016.05.015.

C., Hamde, Dipali, and Rathi V. Pratiksha. 2020. “Formulation, Evaluation And Aantimicrobial Activity Of Annona Reticulata L ( Ramphal ) Micro Susupension.” 9(10):1841–60. doi: 10.20959/wjpps202010-17291.

Hendradi, Esti, and Mochammad Yuwono. 2016. “Efek Perbandingan Surfaktan Dan Kosurfaktan Terhadap Karakteristik Dan E Fi Siensi Penjebakan Ovalbumin Dalam Mikroemulsi Esti Hendradi Dan Mochammad Yuwono.” Jurnal Farmasi Indonesia 8(1):310–19.

Hidayat, Asep, Apri Heri Iswanto, Arida Susilowati, and Henti Hendalastuti Rachmat. 2018. “Radical Scavenging Activity of Kemenyan Resin Produced by an Indonesian Native Plant, Styrax Sumatrana1.” Journal of the Korean Wood Science and Technology 46(4):346–54. doi: 10.5658/WOOD.2018.46.4.346.

Hong, Chi Rac, Gyu Whan Lee, Hyun Dong Paik, Pahn Shick Chang, and Seung Jun Choi. 2017. “Influence of Lysolecithin and Tween 80 on the Colloidal Stability of Branched Chain Amino Acids in a Nanosuspension System.” Food Chemistry 221:606–12. doi: 10.1016/j.foodchem.2016.11.131.

Jadhav, A. B., P. R. Gawandar, and G. Vitore. 2018. “Formulation and Evaluation of Amoxicillin Nanosuspension.” International Journal of Universal Print (04):211–21.

Jayusman. 2014. Mengenal Pohon Kemenyan ( Styrax Spp.) Jenis Dengan Spektrum Pemanfaatan Luas Yang Belum Dioptimalkan. edited by M. Na’iem, Mafudz, and S. Prabawa. Jakarta: IPB Press.

Kiswandono, Agung Abadi, Apri Heri Iswanto, Arida Susilowati, and Agnes Farida Lumbantobing. 2016. “Analisis Kandungan Asam Sinamat Dan Skrining Fitokimia Getah Kemenyan Jenis Bulu (Styrax Benzoine Var. Hiliferum) Dari Tapanuli Utara.” Pp. 146–55 in, edited by P. . Prof. Ir. Surya Hadi, M.Sc, P. D. Y. M. Syah, P. D. E. H. Hakim, P. D. S. A. Ahmad, P. D. A. B. Setiaji, P. . Dedy Suhendra, and P. . Erin Ryantin Gunawan. Lombok: Program Studi Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mataram.

Malkin, Rhonda. 2006. Handbook of Pharmaceutical Excipients Fifth Edition Edited. 5th ed. edited by R. C. Rowe, P. J. Sheskey, and S. C. Owen. Washington: Pharmaceutical Press.

Melinda Harahap, Minta Ito. 2019. “Pengalaman Masyarakat Pakpak Bharat Merawat Luka Menggunakan Kemenyan.” Jurnal Maternitas Kebidanan 4(2):62. doi: 10.34012/jumkep.v4i2.736.

Muhammad Suhail, Ashok Kumar Janakiraman, Arshad Khan, Abid Naeem, and Syed Faisal Badshah. 2019. “Surfactants and Their Role in Pharmaceutical Product Development: An Overview.” Journal of Pharmacy and Pharmaceutics 6(2):72–82. doi: 10.15436/2377-1313.19.2601.

Nagare, SK, SM Ghurghure, AB Khade, SG Jadhav, and SB Salunkhe. 2012. “A Review on Nanosuspensions An Innovative Acceptable Approach in Novel Delivery System.” Indian Journal of Novel Drug Delivery 4(3):189–201.

Nayak, Amit Kumar, and Prachi Prava Panigrahi. 2012. “Solubility Enhancement of Etoricoxib by Cosolvency Approach.” 2012. doi: 10.5402/2012/820653.

P Simatupang, Dedi, Nora Susanti, and Jamalum Purba. 2021. “Stability of Styrax Benzoin Extract and Fraction with the Addition of Glycerol and Tween 80.” Jurnal Pendidikan Kimia 13(2):143–50. doi: 10.24114/jpkim.v13i2.26986.

Pujiharti, Rina, Metta Dewi, and Nengah Dhiasa. 2015. “Pengaruh Perbedaan Pembuatan Dengan Metode Dispersi Dan Presipitasi Pada Karakteristik Fisik Dan Rasio Kekeruhan Suspensi Kloramfenikol.” Jurnal Farmasetis 4(1):2–7.

Regina, Oktabella, Hendar Sudrajad, and Dina Syaflita. 2019. “Measurement of Viscosity Uses an Alternative Viscometer.” Jurnal Geliga Sains: Jurnal Pendidikan Fisika 6(2):127. doi: 10.31258/jgs.6.2.127-132.

Saeedi, Majid, Mohammad Reza Rafati, Katayoun Morteza-Semnani, Atieh Yazdani Rostam, and Hamid Reza Kelidari. 2015. “Evaluation of Effect of Tween 80 on Characteristics of Tadalafil 0.1% Suspension.” Pharmaceutical and Biomedical Research 1(2):35–43. doi: 10.18869/acadpub.pbr.1.2.35.

Sharif, Atia, Haq Nawaz, Rehman Rafia, Mushtaq Ayesha, and Umer Rashid. 2016. “A Review on Bioactive Potential of Benzoin Resin.” International Journal of Chemical and Biochemical Sciences 10(January):106–10.

Siregar, R. V., D. Suryanto, and Yurnaliza. 2019. “Antibacterial Ability of Endophytic Bacteria Isolated from Kemenyan (Styrax Benzoin L.).” IOP Conference Series: Earth and Environmental Science 305(1):0–5. doi: 10.1088/1755-1315/305/1/012054.

Suena, Ni Made Dharma Shantini. 2020. “Evaluasi Fisik Sediaan Suspensi Dengan Kombinasi Suspending Agent PGA (Pulvis Gummi Arabici) Dan CMC-Na (Carboxymethylcellulosum Natrium).” Jurnal Ilmiah Medicamento 1(1):33–38. doi: 10.36733/medicamento.v1i1.724.

Susanti, Nora, Jamalum Purba, and Dedi P. Simatupang. 2021. “Increased Stability of Styrax Benzoin Extract and Fraction with the Addition of Cosolvents.” Journal of Physics: Conference Series 1819(1). doi: 10.1088/1742-6596/1819/1/012049.

Wang, Cheng, Yu Yang, Xiaohong Cui, Shangwu Ding, and Zhong Chen. 2020. “Three Different Types of Solubilization of Thymol in Tween 80: Micelles, Solutions, and Emulsions- a Mechanism Study of Micellar Solubilization.” Journal of Molecular Liquids 306:112901. doi: 10.1016/j.molliq.2020.112901.

Zhu, Yanqing, Chao Cheng, Gaoquan Chen, and Hongkun Zhao. 2018. “Solubility Modeling and Mixing Properties for Benzoin in Different Monosolvents and Solvent Mixtures at the Temperature Range from 273.15 to 313.15 K.” Journal of Chemical and Engineering Data 63(2):341–51. doi: 10.1021/acs.jced.7b00743.




DOI: https://doi.org/10.24114/jbio.v8i2.33622

Article Metrics

Abstract view : 480 times
PDF - 196 times

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

INDEXING

  

 

 

 

JBIO : Jurnal Biosains (The Journal of Biosciences), Program Studi Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Negeri Medan. ISSN 2443-1230 (print) dan ISSN 2460-6804 (online)

Lisensi Creative Commons
Ciptaan disebarluaskan di bawah Lisensi Creative Commons Atribusi 4.0 Internasional.