ACTIVITY TEST OF SIAM LABU (Sechium edule (Jacq.) Swartz) LEAF EXTRACT ON REDUCTION OF DARAGE URATE ACID TARGETS OF WHITE RATS (Rattus novergicus)

Authors

DOI:

https://doi.org/10.24114/jbio.v9i3.51002

Keywords:

Uric Acid, Extract Siam Labu, Rats, Allopurinol

Abstract

Uric acid is a substance produced from the breakdown of purines or waste products in the body, as a result of purine catabolism aided by the enzymes cguanase and xanthine oxidase. One of the green plants  used as traditional medicine is siam labu (Sechium edule). This plant is a vegetable plant belonging to the Curcubatiacae family that grows in the highlands. The purpose of this study was to test the anti-gout activity of chayote leaves in male  rats. The method used in this study started from preparing simplisia, preparing siam labu leaf extract, inducing mice with Ca-oxanate at a dose of 250 mg/kgBW and administering siam labu leaf extract at a dose of 250 mg/kgBW, 500 mg/kgBW. and 750 mg/kgBW was administered orally with intermittent observation periods of 1 hour for 6 hours. Results obtained in rats given 750 mg/kgBW of extract showed the lowest reduction of 3.88 ± 0.3 mg/dl. One-way ANOVA results  obtained a significant value p=0.00 (p<0.05), which can be concluded that there are differences in each treatment method in experimental animals. Tukey test results can be seen at 6 hours, it can be concluded that EDLS 750 mg/kg body weight with allopurinol is not significantly different.

Author Biography

Sofia Rahmi Tambusai, Institut Kesehatan Deli Husada Deli Tua

Pengujian antidiabetes dari daun tekelan (Chromolaena odorata L.)

References

Arifurahman. (2017). Effect of Siam Labu Leaf Extract (Sechhium sdule (Jacq.) Swartz) on the Growth Inhibition of Prophyromonas gingivalis Bacteria Causing Periodentitis. Surakarta: Faculty of Dentistry. University of Muhammadiyah Surakarta.

Ningtiyas, I.F., dan Ramadhian, M.R. (2016). Effectiveness of Salam Leaf Extract to Lower Uric Acid Levels in Arthritis Patients Patients with Arthritis Gout. Majority. 5(3): 105-110.

Priantono,H. (2005). Siam Labu for Hypertension. http://www.pjbs.org/pjnonline/fin134.pdf.

Putra, T.R. Hyperurisemia. In: Sudoyo, A.W. editor. Textbook of internal medicine. 4. Jakarta: Publishing Center of the Department of Internal Medicine Faculty University of Indonesia. Pages. 1123-1127.

Rizki, N.D., Sesiarso, S., Situmorang, A. (2014). Antioxidant Activity Test of Ethanol Extract of Siamese Pumpkin Leaf (Sechium edule (Jacq.)Sw) based on the activity of SOD and MDA in Sheep Red Blood Cells Red Blood Cells Experiencing Oxidative Stress in In Vitro. Science Journal of Pharmacy. 2(1): 32-36.

Sultani, P. (2014). Efectiveness of juice Siamese Pumpkin (Sechium edule (Jacq.) Sw) as Anti Hypertension in White Rats Male Spraguse-Dawlay Induced NaCl. Bogor: FMIPA Universitas PAKUAN.

Tayeb, R., Ubyaan, M., and Usman. (2016). Effective Test Of Ethanol Extract Of Sirsak Leaves (Anonna muricata L.) on uric acid levels in white mice (Rattus norvegicus). Proceedings of the National Seminar on Indonesian Medicinal Plants. Pages. 367-373.

Downloads

Published

2023-11-30