The Effect of Date Fruit (Phoenix dactylifera L.) Consumption on Autonomic Nerve Function and Hot Flash Manifestations in Menopausal Women
DOI:
https://doi.org/10.24114/mymr1g24Keywords:
Autonomic Nerve Function; Hot Flashes; Menopause; Date FruitAbstract
Menopause is a natural phase in a woman’s life marked by decreased estrogen levels and symptoms such as hot flashes, which are linked to autonomic nervous system dysfunction. Hot flashes cause sudden heat sensations, sweating, flushing, and palpitations that can disrupt daily life. Date fruit is rich in antioxidants and phytoestrogens, making it a potential non-hormonal alternative to alleviate menopausal symptoms. This study aimed to analyze the effect of date fruit consumption on autonomic nerve function and hot flash manifestations in menopausal women. A quasi-experimental pretest–posttest control group design was used, involving menopausal women aged 45–60 years experiencing hot flashes at Midwife Hj. Dewi Sesmera’s Clinic, Medan City, North Sumatra. Participants were selected using purposive sampling. The intervention group consumed 50 grams of date fruit daily for eight weeks. Data were collected through questionnaires, interviews, and documentation. Autonomic nerve function was measured using the COMPASS-31 (Composite Autonomic Symptom Score-31), and hot flash frequency and intensity were assessed with the Menopause Rating Scale (MRS). Statistical analysis employed a paired t-test (p < 0.05) using SPSS version 24. Results showed that while improvement in autonomic nerve function was not statistically significant, the frequency and intensity of hot flashes significantly decreased in the intervention group.
References
Al-Farsi, M., Alasalvar, C., Morris, A., Baron, M., & Shahidi, F. (2005). Compositional and sensory characteristics of three native date varieties grown in Oman. Journal of Agricultural and Food Chemistry, 53(19), 7586–7591. https://doi.org/10.1021/jf050578y
Baliga, M. S., Baliga, B. R. V., Kandathil, S. M., Bhat, H. P., & Vayalil, P. K. (2011). A review of the chemistry and pharmacology of the date fruits (Phoenix dactylifera L.). Food Research International, 44(7), 1812–1822. https://doi.org/10.1016/j.foodres.2010.07.004
Elkins, G., et al. (2025). User outcomes for an app-delivered hypnosis intervention for menopausal hot flashes: Retrospective analysis. JMIR Formative Research, 9, e63948. https://formative.jmir.org/2025/1/e63948/
Fenske, W., Knaack, S., Meyer, J., et al. (2024). Heart rate variability biofeedback improves autonomic function and functional outcome in patients with critical illness polyneuropathy: A randomized controlled trial. Frontiers in Neuroscience, 18, 11554868. https://pmc.ncbi.nlm.nih.gov/articles/PMC11554868/
Freedman, R. R. (2005). Hot flashes: Behavioral treatments, mechanisms, and relation to sleep. The American Journal of Medicine, 118(Suppl 12B), 124–130. https://doi.org/10.1016/j.amjmed.2005.09.046
Freeman, E. W. (2010). Associations of depression with the transition to menopause. Menopause, 17(4), 823–827. https://doi.org/10.1097/gme.0b013e3181db9f8b
Kadakia, K. C., Loprinzi, C. L., & Barton, D. L. (2012). Hot flashes: The ongoing search for effective interventions. Menopause, 19(7), 719–721. https://doi.org/10.1097/gme.0b013e3182578d31
Karalis, S., Karalis, T., Malakoudi, F., Thanasas, I., Kleisiari, A. S., Tzeli, Z., Papavasiliou, E., & Karalis, D. T. (2023). Role of phytoestrogen in menopausal women with depressive symptoms: A consecutive case series study. Cureus, 15(4), e37222. https://doi.org/10.7759/cureus.37222
Li, J., Li, H., Yan, P., et al. (2021). Efficacy and safety of phytoestrogens in the treatment of perimenopausal and postmenopausal depressive disorders: A systematic review and meta-analysis. International Journal of Clinical Practice, 75(0), e14360. https://doi.org/10.1111/ijcp.14360
Liu, L., Wang, X., Zhang, J., et al. (2024). Acupuncture improves autonomic nervous function and ghrelin levels in patients with postprandial distress syndrome: A randomized controlled trial. Chinese Medicine, 19(1), 1028. https://doi.org/10.1186/s13020-024-01028-3
Maki, P. M., & Thurston, R. C. (2020). Menopause and brain health: Hormonal changes are only part of the story. Frontiers in Aging Neuroscience, 12, 571991. https://doi.org/10.3389/fnagi.2020.571991
Messina, M. (2014). Soy foods, isoflavones, and the health of postmenopausal women. The American Journal of Clinical Nutrition, 100(Suppl 1), 423S–430S. https://doi.org/10.3945/ajcn.113.071464
Mulyadi, F. E. (2022). Pengaruh konsumsi buah kurma Ajwa (Phoenix dactylifera L.) terhadap kadar hormon anti-Mullerian (AMH) perempuan perimenopause (Disertasi). Universitas Hasanuddin. https://doi.org/10.33024/mahesa.v4i6.14458
Mulyadi, F. E., Natsir, R., Mappaware, N. A., As'ad, S., Sinrang, A. W., & Kurniawan, L. B. (2023). Pengaruh pemberian buah kurma Ajwa (Phoenix dactylifera L.) terhadap kadar hormon anti-Mullerian (AMH) dan gambaran klinis perempuan perimenopause. Jurnal Kesehatan Reproduksi, 10(1), 1–9. https://doi.org/10.22146/jkr.72298
Rondanelli, M., Faliva, M., Miccono, A., Naso, M., Nichetti, M., Riva, A., et al. (2018). Food pyramid for subjects with chronic pain: Foods and dietary constituents as anti-inflammatory and antioxidant agents. Nutrition Research Reviews, 31(1), 1–21. https://doi.org/10.1017/S0954422417000270
Rossouw, J. E., Anderson, G. L., Prentice, R. L., LaCroix, A. Z., Kooperberg, C., Stefanick, M. L., et al. (2002). Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. JAMA, 288(3), 321–333. https://doi.org/10.1001/jama.288.3.321
Shirdel, E., Rahimi, F., Jafarzadeh, M., Abdi, M., & Rahnemaei, F. A. (2025). Improving female health at various life stages: A systematic review of the impact of date fruit products. Sultan Qaboos University Medical Journal, 25(1), 38–49. https://doi.org/10.18295/squmj.10.2024.06
Sobral, M. V. S., et al. (2025). Efficacy and safety of elinzanetant in vasomotor symptoms associated with menopause: A meta-analysis of randomized controlled trials. European Journal of Obstetrics & Gynecology and Reproductive Biology, 307, 142–147. https://pubmed.ncbi.nlm.nih.gov/
Soules, M. R., Sherman, S., Parrott, E., Rebar, R., Santoro, N., Utian, W., et al. (2001). Executive summary: Stages of Reproductive Aging Workshop (STRAW). Climacteric, 4(4), 267–272. https://doi.org/10.1016/s0015-0282(01)02909-0
Tan, L., Yan, W., Yang, W., Kamionka, A., Lipowski, M., Zhao, Z., et al. (2023). Effect of exercise on inflammatory markers in postmenopausal women with overweight and obesity: A systematic review and meta-analysis. Experimental Gerontology, 183, 112310. https://doi.org/10.1016/j.exger.2023.112310
Thurston, R. C., Christie, I. C., & Matthews, K. A. (2010). Hot flashes and cardiac vagal control during women’s daily lives. Menopause, 17(3), 473–479. https://doi.org/10.1097/gme.0b013e3181c7de53
Trigg, A., et al. (2024). Design of OASIS 1 and 2: Phase 3 clinical trials assessing the efficacy and safety of elinzanetant for the treatment of vasomotor symptoms associated with menopause. Menopause, 31(6), 522–529. https://pubmed.ncbi.nlm.nih.gov/
von Känel, R., Kristiansen, N. N., Christensen, J. V., et al. (2024). Mindfulness-based stress reduction reduces sympathetic nerve activity reactivity to mental stress in patients with chronic kidney disease: Results from a randomized pilot trial. Frontiers in Psychiatry, 15, 11065017. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11065017/
Wang, Q., Zhao, Y., Huang, L., et al. (2025). Effects of transcutaneous vagus nerve stimulation combined with standard physiotherapy on autonomic function and pain in patients with chronic neck pain: A randomized controlled trial. Journal of Clinical Medicine, 14(1), 153. https://www.mdpi.com/2077-0383/14/1/153
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Winda Maulinasari Nasution, Siti Maryam Hasibuan, Lanny Apriani

This work is licensed under a Creative Commons Attribution 4.0 International License.
For Authors Jurnal Biosains agree to the following terms:
Authors retain copyright and grant the Jurnal Biosains (JBIO) right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-SA 4.0) that allows others to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) the work for any purpose, even commercially with an acknowledgement of the work's authorship and initial publication in JBIO (Jurnal Biosains)
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in JBIO (Jurnal Biosains)
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).


