Implementation of green chemistry approaches in chemistry labs instruction: A systematic literature review

Authors

DOI:

https://doi.org/10.24114/jpkim.v16i3.65184

Keywords:

Chemistry laboratory, Environmental awareness, Green chemistry, Higher education, Practical skills

Abstract

In recent years, the urgent need to address environmental problems has driven green chemistry in various disciplines, focusing on designing chemical products and processes that minimize hazardous materials. This research conducted a systematic literature review (SLR) to evaluate the application of green chemistry in higher education chemistry lab practices and its impact on students' conceptual understanding, practical skills, and environmental awareness. Using the PRISMA method, 46 articles were analyzed from the Scopus and ScienceDirect databases extracted from a total of 537 published between 2015 and 2024. The findings show that applying green chemistry in chemistry laboratory learning can improve students' conceptual understanding, practical skills, and environmental awareness while encouraging environmentally friendly synthesis methods. However, challenges such as limited resources and the need for additional training for lecturers still exist. Institutional support and professional development are needed to maximize implementation. In conclusion, green chemistry has great potential to create a more environmentally responsible generation of chemists, with recommendations for comprehensive integration into chemistry curricula and increased support for educators to address implementation challenges. This study provides a basis for expanding the application of green chemistry in chemistry education and preparing students to face future sustainability challenges.

References

Abraham, L. (2020). A Green Nucleophilic Aromatic Substitution Reaction. Journal of Chemical Education, 97 (10), 3810–3815. https://doi.org/10.1021/acs.jchemed.0c00181

Amaris, Z.N., Freitas, D.N., Mac, K., Gerner, K.T., Nameth, C., & Wheeler, K.E. (2017). Nanoparticle Synthesis, Characterization, and Ecotoxicity: A Research-Based Set of Laboratory Experiments for a General Chemistry Course. Journal of Chemical Education, 94 (12), 1939–1945. https://doi.org/10.1021/acs.jchemed.7b00369

Andrew, O. B., Sherwood, J., & Hurst, G. A. (2022). A Greener Synthesis of the Antidepressant Bupropion Hydrochloride. Journal of Chemical Education , 99 (9), 3277–3282. https://doi.org/10.1021/acs.jchemed.2c00581

Ang, J. W. J. (2021). Integrating Green Chemistry into Teaching Laboratories: Aqueous Suzuki-Miyaura Cross-Coupling Reaction Using a Recyclable Fluorous Precatalyst. Journal of Chemical Education, 98 (1), 203–207. https://doi.org/10.1021/acs.jchemed.0c00072

Armstrong, L. B., Rivas, M. C., Zhou, Z., Douskey, M. C., & Baranger, A. M. (2024). Behind the Scenes of Teaching Green: An Iterative Approach to Curriculum Design and Implementation in the General Chemistry Laboratory. Journal of Chemical Education, 101(8), 3264-3275. https://doi.org/10.1021/acs.jchemed.4c00176

Armstrong, L.B., Rivas, MC, Zhou, Z., Irie, L.M., Kerstiens, GA, Robak, MAT, Douskey, MC, & Baranger, A.M. (2019). Developing a Green Chemistry Focused General Chemistry Laboratory Curriculum: What Do Students Understand and Value about Green Chemistry? Journal of Chemical Education, 96 (11), 2410–2419. https://doi.org/10.1021/acs.jchemed.9b00277

Baldwin, O.W.M., Conrad-Marut, L.H., Beutner, G.L., & Vosburg, D.A. (2022). Facile Amide Bond Formation with TCFH-NMI in an Organic Laboratory Course. Journal of Chemical Education, 99 (11), 3747–3751. https://doi.org/10.1021/acs.jchemed.2c00760

Biswas, R., & Mukherjee, A. (2017). Introducing the Concept of Green Synthesis in the Undergraduate Laboratory: Two-Step Synthesis of 4-Bromoacetanilide from Aniline. Journal of Chemical Education, 94 (9), 1391–1394. https://doi.org/10.1021/acs.jchemed.6b00749

Chen, T.L., Kim, H., Pan, S.Y., Tseng, P.C., Lin, Y.P., & Chiang, P.C. (2020). Implementation of green chemistry principles in circular economy system towards sustainable development goals: Challenges and perspectives. Science of the Total Environment, 716 (1), 136998. https://doi.org/10.1016/j.scitotenv.2020.136998

Contreras-Cruz, D.A., Cantú-Reyes, M., Garciá-Sánchez, J.M., Penã-Ortíz, D., Sánchez-Carmona, M.A., & Miranda, L.D. (2019). Shedding Blue Light on the Undergraduate Laboratory: An Easy-to-Assemble LED Photoreactor for Aromatization of a 1,4-Dihydropyridine. Journal of Chemical Education, 96 (9), 2015–2020. https://doi.org/10.1021/acs.jchemed.8b01026

Cooper, P. D., & Walser, J. (2019). Total Chemical Footprint of an Experiment: A Systems Thinking Approach to Teaching Rovibrational Spectroscopy. Journal of Chemical Education, 96 (12), 2947–2951. https://doi.org/10.1021/acs.jchemed.9b00405

Cosio, M.N., Cardenal, A.D., Maity, A., Hyun, S.M., Akwaowo, V.E., Hoffman, C.W., Powers, T.M., & Powers, D.C. (2020). Exploring Green Chemistry with Aerobic Hypervalent Iodine Catalysis. Journal of Chemical Education, 97 (10), 3816–3821. https://doi.org/10.1021/acs.jchemed.0c00410

Davila-Diaz, K. (2024). On-the-Go Lab for Aqueous Reactions Demonstrations: Activities at the Microscale. Journal of Chemical Education, 101 (5), 2149–2155. https://doi.org/10.1021/acs.jchemed.3c01317

de Marco, B. A., Rechelo, B. S., Tótoli, E. G., Kogawa, A. C., & Salgado, H. R. N. (2019). Evolution of green chemistry and its multidimensional impacts: A review. Saudi Pharmaceutical Journal, 27(1), 1-8. https://doi.org/10.1016/j.jsps.2018.07.011

Dhollande, S., Taylor, A., Meyer, S., & Scott, M. (2021). Conducting integrative reviews: a guide for novice nursing researchers. Journal of Research in Nursing, 26(5), 427-438. https://doi.org/10.1177/1744987121997907

Dicks, A.P., D'Eon, J.C., Morra, B., Kutas Chisu, C., Quinlan, K.B., & Cannon, A.S. (2019). A Systems Thinking Department: Fostering a Culture of Green Chemistry Practice among Students. Journal of Chemical Education, 96 (12), 2836–2844. https://doi.org/10.1021/acs.jchemed.9b00287

Edwards, P., Zhang, W., Belton, B., & Little, D. C. (2019). Misunderstandings, myths and mantras in aquaculture: Its contribution to world food supplies has been regularly over reported. Marine Policy, 106. https://doi.org/10.1016/j.marpol.2019.103547

Fennie, M. W., & Roth, J. M. (2016). Comparing Amide-Forming Reactions Using Green Chemistry Metrics in an Undergraduate Organic Laboratory. Journal of Chemical Education, 93 (10), 1788–1793. https://doi.org/10.1021/acs.jchemed.6b00090

Flemming, K., Booth, A., Garside, R., Tunçalp, Ö., & Noyes, J. (2019). Qualitative evidence synthesis for complex interventions and guideline development: clarification of the purpose, designs and relevant methods. BMJ Global Health, 4 (Suppl 1), e000882. https://doi.org/10.1136/bmjgh-2018-000882

Ganesh, K. N., Zhang, D., Miller, S. J., Rossen, K., Chirik, P. J., Kozlowski, M. C., ... & Voutchkova-Kostal, A. M. (2021). Green chemistry: a framework for a sustainable future. Organometallics, 40(12), 1801-1805. https://doi.org/10.1021/acs.organomet.1c00343

Gormong, E.A., Wentzel, M.T., Cao, B., Kundel, L.N., Reineke, T.M., & Wissinger, J.E. (2021). Exploring Divergent Green Reaction Media for the Copolymerization of Biobased Monomers in the Teaching Laboratory. Journal of Chemical Education, 98 (2), 559–566. https://doi.org/10.1021/acs.jchemed.0c00688

Gusenbauer, M., & Haddaway, N. R. (2021). What every researcher should know about searching – clarified concepts, search advice, and an agenda to improve finding in academia. Research Synthesis Methods, 12 (2), 136–147. https://doi.org/10.1002/jrsm.1457

Harrypersad, S., & Canal, J. P. (2023). The Synthesis of Ruthenocene─ A Methodology Appropriate for the Inorganic Undergraduate Curriculum. Journal of Chemical Education, 100(3), 1320-1325. https://doi.org/10.1021/acs.jchemed.2c01258

Hie, L., Chang, J. J., & Garg, N. K. (2015). Nickel-catalyzed Suzuki-Miyaura cross-coupling in a green alcohol solvent for an undergraduate organic chemistry laboratory. Journal of Chemical Education, 92, pp. 571–574. https://doi.org/10.1021/ed500158p

Hopson, R., Lee, P. Y. B., & Hess, K. M. (2018). 1-Dimensional selective nuclear overhauser effect NMR spectroscopy to characterize products from a two-step green chemistry synthesis. Journal of Chemical Education, 95(4), 641-647. https://doi.org/10.1021/acs.jchemed.7b00494

Howard, D.M., Adams, M.J., Clarke, T.-K., Hafferty, J.D., Gibson, J., Shirali, M., Coleman, J.R., Hagenaars, S.P., Ward, J., Wigmore, E.M., & Alloza, C. (2019). Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions David. Nature Neuroscience, 22 (3), 343–352. https://doi.org/https://doi.org/10.1038/s41593-018-0326-7

Hurst, GA, Slootweg, JC, Balu, A.M., Climent-Bellido, M.S., Gomera, A., Gomez, P., Luque, R., Mammino, L., Spanevello, R.A., Saito, K., & Ibanez, J.G. (2019). International Perspectives on Green and Sustainable Chemistry Education via Systems Thinking [Research-article]. Journal of Chemical Education, 96 (12), 2794–2804. https://doi.org/10.1021/acs.jchemed.9b00341

Keen, C., Couture, S., Abd El Meseh, N., & Sevian, H. (2020). Connecting Theory to Life: Learning Greener Electrochemistry by Taking Apart a Common Battery. Journal of Chemical Education, 97 (4), 934–942. https://doi.org/10.1021/acs.jchemed.9b00840

Knutson, CM, Hilker, AP, Tolstyka, ZP, Anderson, CB, Wilbon, PA, Mathers, RT, Wentzel, MT, Perkins, AL, & Wissinger, JE (2019). Dyeing to Degrade: A Bioplastics Experiment for College and High School Classrooms. Journal of Chemical Education, 96 (11), 2565–2573. https://doi.org/10.1021/acs.jchemed.9b00461

Knutson, C. M., Schneiderman, D. K., Yu, M., Javner, C. H., Distefano, M. D., & Wissinger, J. E. (2017). Polymeric Medical Sutures: An Exploration of Polymers and Green Chemistry. Journal of Chemical Education, 94 (11), 1761–1765. https://doi.org/10.1021/acs.jchemed.6b00835

Kraus, S., Breier, M., & Dasí-Rodríguez, S. (2020). The art of crafting a systematic literature review in entrepreneurship research. International Entrepreneurship and Management Journal, 16, 1023-1042. https://doi.org/10.1007/s11365-020-00635-4

Landstrom, E. B., Nichol, M., Lipshutz, B. H., & Gainer, M. J. (2019). Discovery-Based SNAr Experiment in Water Using Micellar Catalysis. Journal of Chemical Education, 96 (11), 2668–2671. https://doi.org/10.1021/acs.jchemed.9b00310

Lapanantnoppakhun, S., Tengjaroensakul, U., Mungkornasawakul, P., Puangpila, C., Kittiwachana, S., Saengtempiam, J., & Hartwell, SK (2020). Green Analytical Chemistry Experiment: Quantitative Analysis of Iron in Supplement Tablets with Vis spectrophotometry Using Tea Extract as a Chromogenic Agent. Journal of Chemical Education, 97 (1), 207–214. https://doi.org/10.1021/acs.jchemed.9b00530

Lasker, GA, Simcox, NJ, Mellor, KE, Mullins, ML, Nesmith, SM, Van Bergen, S., & Anastas, PT (2019). Introducing Toxicology into the Undergraduate Chemistry Laboratory Using Safety Data Sheets and Sunscreen Activities. Journal of Chemical Education, 96 (4), 720–724. https://doi.org/10.1021/acs.jchemed.8b00408

Leslie, J. M., & Tzeel, B. A. (2016). Gold(III)-Catalyzed Hydration of Phenylacetylene. Journal of Chemical Education, 93 (6), 1100–1102. https://doi.org/10.1021/acs.jchemed.5b00628

Lin, X., Jin, X., Xu, C., Lai, H., Lin, M., Ren, N., & Cai, L. (2023). Iodometric Titration on Microfluidic Paper-Based Analytical Devices for Determination of Ascorbic Acid: A Laboratory Experiment for Chemical Education Undergraduates. Journal of Chemical Education, 100 (5), 1997–2002. https://doi.org/10.1021/acs.jchemed.2c01236

Liu, Y., Myers, E. J., Rydahl, S. A., & Wang, X. (2019). Ultrasonic-Assisted Synthesis, Characterization, and Application of a Metal-Organic Framework: A Green General Chemistry Laboratory Project. Journal of Chemical Education, 96 (10), 2286–2291. https://doi.org/10.1021/acs.jchemed.9b00267

Lu, G. ping, Chen, F., & Cai, C. (2017). Thiourea in the Construction of CS Bonds as Part of an Undergraduate Organic Chemistry Laboratory Course. Journal of Chemical Education, 94, pp. 244–247. https://doi.org/10.1021/acs.jchemed.6b00232

Mohan, R. S., & Mejia, M. P. (2020). Environmentally Friendly Organic Chemistry Laboratory Experiments for the Undergraduate Curriculum: A Literature Survey and Assessment. Journal of Chemical Education, 97 (4), 943–959. https://doi.org/10.1021/acs.jchemed.9b00753

Mooney, M., Vreugdenhil, A. J., & Shetranjiwalla, S. (2020). A Toolkit of Green Chemistry and Life-Cycle Analysis for Comparative Assessment in Undergraduate Organic Chemistry Experiments: Synthesis of (E)-Stilbene. Journal of Chemical Education, 97 (5), 1336–1344. https://doi.org/10.1021/acs.jchemed.9b00697

O'Neil, N.J., Scott, S., Relph, R., & Ponnusamy, E. (2021). Approaches to Incorporating Green Chemistry and Safety into Laboratory Culture. Journal of Chemical Education, 98 (1), 84–91. https://doi.org/10.1021/acs.jchemed.0c00134

Obhi, N. K., Mallov, I., Borduas-Dedekind, N., Rousseaux, S. A. L., & Dicks, A. P. (2019). Comparing Industrial Amination Reactions in a Combined Class and Laboratory Green Chemistry Assignment. Journal of Chemical Education, 96 (1), 93–99. https://doi.org/10.1021/acs.jchemed.8b00578

Oliveira, J. R. P., Tusset, A. M., Andrade, D. I., Balthazar, J. M., Pagani, R. N., & Lenzi, G. G. (2024). Action Plans Study: Principles of Green Chemistry, Sustainable Development, and Smart Cities. Sustainability, 16(18), 8041

Othman, KA, Omer, RA, Mohammad, AAA, & Safin, DA (2024). Green Approaches for Efficient Functional Group Analysis of Organic Compounds. Journal of Chemical Education, 101 (2), 567–577. https://doi.org/10.1021/acs.jchemed.3c00809

Paristiowati, M., Rahmawati, Y., Fitriani, E., Satrio, JA, & Hasibuan, NAP (2022). Developing Preservice Chemistry Teachers' Engagement with Sustainability Education through an Online, Project-Based Learning Summer Course Program. Sustainability (Switzerland), 14 (3). https://doi.org/10.3390/su14031783

Pfab, E., Filiciotto, L., & Luque, R. (2019). The Dark Side of Biomass Valorization: A Laboratory Experiment to Understand Humin Formation, Catalysis, and Green Chemistry. Journal of Chemical Education, 96 (12), 3030–3037. https://doi.org/10.1021/acs.jchemed.9b00410

Płotka-Wasylka, J., Mohamed, H. M., Kurowska-Susdorf, A., Dewani, R., Fares, M. Y., & Andruch, V. (2021). Green analytical chemistry as an integral part of sustainable education development. Current Opinion in Green and Sustainable Chemistry, 31, 100508. https://doi.org/10.1016/j.cogsc.2021.100508

Quinson, J. (2023). Room Temperature Surfactant-Free Syntheses of Gold Nanoparticles in Alkaline Mixtures of Water and Alcohols: A Model System to Introduce Nanotechnology and Green Chemistry to Future Chemists and Engineers. Journal of Chemical Education, 100 (9), 3612–3619. https://doi.org/10.1021/acs.jchemed.3c00492

Rattanakit, P., & Maungchang, R. (2019). Determining Iron(III) Concentration in a Green Chemistry Experiment Using Phyllanthus emblica (Indian Gooseberry) Extract and Spectrophotometry. Journal of Chemical Education, 96 (4), 756–760. https://doi.org/10.1021/acs.jchemed.8b00817

Reyes, K.M.D., Bruce, K., & Shetranjiwalla, S. (2023). Green Chemistry, Life Cycle Assessment, and Systems Thinking: An Integrated Comparative-Complementary Chemical Decision-Making Approach. Journal of Chemical Education, 100 (1), 209–220. https://doi.org/10.1021/acs.jchemed.2c00647

Ritter, S., & Abraham, L. (2022). A Green and Efficient Cyclization of Citronellal into Isopulegol: A Guided-Inquiry Organic Chemistry Laboratory Experiment. Journal of Chemical Education, 99 (12), 4134–4142. https://doi.org/10.1021/acs.jchemed.2c00351

Sarkis-Onofre, R., Catalá-López, F., Aromataris, E., & Lockwood, C. (2021). How to properly use the PRISMA Statement. Systematic Reviews, 10 (117), 1-3. https://doi.org/10.1186/s13643-021-01671-z

Shaffril, HAM, Ahmad, N., Samsuddin, SF, Samah, AA, & Hamdan, ME (2020). Systematic literature review on adaptation towards climate change impacts among indigenous people in the Asia Pacific region. Journal of Cleaner Production, 258, 120595. https://doi.org/10.1016/j.jclepro.2020.120595

Sharma, P., & Ponnusamy, E. (2022). DOZNTM 2.0: A quantitative green chemistry evaluator for a sustainable future. Journal of Organometallic Chemistry, 970 – 971, 122367. https://doi.org/10.1016/j.jorganchem.2022.122367

Sharma, R.K., Yadav, S., Gupta, R., & Arora, G. (2019). Synthesis of Magnetic Nanoparticles Using Potato Extract for Dye Degradation: A Green Chemistry Experiment. Journal of Chemical Education, 96 (12), 3038–3044. https://doi.org/10.1021/acs.jchemed.9b00384

Sues, P. E., Cai, K., McIntosh, D. F., & Morris, R. H. (2015). Template effect and ligand substitution methods for the synthesis of iron catalysts: A two-part experiment for inorganic chemistry. Journal of Chemical Education, 92 (2), 378–381. https://doi.org/10.1021/ed500341p

USEPA, 2017. How EPA Evaluates the Safety of Existing Chemicals. https://www.epa.gov/assessing-and-managing-chemicals-under-tsca/how-epa-evaluates-safety-existing-chemicals

Verdía, P., Santamarta, F., & Tojo, E. (2017). Synthesis of (3-Methoxycarbonyl)coumarin in an Ionic Liquid: An Advanced Undergraduate Project for Green Chemistry. Journal of Chemical Education, 94 (4), 505–509. https://doi.org/10.1021/acs.jchemed.6b00148

Waked, AE, Demmans, KZ, Hems, RF, Reyes, LM, Mallov, I., Daley, E., Hoch, LB, Mastronardi, ML, De La Franier, BJ, Borduas-Dedekind, N., & Dicks, AP (2019). The Green Chemistry Initiative's contributions to education at the University of Toronto and beyond. Green Chemistry Letters and Reviews, 12 (2), 187–195. https://doi.org/10.1080/17518253.2019.1609597

Wang, X., Chrzanowski, M., & Liu, Y. (2020). Ultrasonic-Assisted Transesterification: A Green Miniscale Organic Laboratory Experiment. Journal of Chemical Education, 97 (4), 1123–1127. https://doi.org/10.1021/acs.jchemed.9b00956

Wójcik, S., Ciepiela, F., Baś, B., & Jakubowska, M. (2022). Deep learning assisted distinguishing of honey seasonal changes using quadruple voltammetric electrodes. Talanta, 241, 123213. https://doi.org/10.1016/j.talanta.2022.123213

Wu, N., Kubo, T., Sekoni, K.N., Hall, A.O., Phadke, S., Zurcher, D.M., Wallace, R.L., Kothari, D.B., & McNeil, A.J. (2019). Student-Designed Green Chemistry Experiment for a Large-Enrollment, Introductory Organic Laboratory Course. Journal of Chemical Education, 96 (11), 2420–2425. https://doi.org/10.1021/acs.jchemed.9b00375

Xiao, Y., Liu, Z., Gu, H., Yang, F., Zhang, L., & Yang, L. (2021). Improved method to obtain essential oil, asarinin and sesamin from Asarum heterotropoides var. mandshuricum using microwave-assisted steam distillation followed by solvent extraction and antifungal activity of essential oil against Fusarium spp. Industrial Crops and Products, 162, 113295. https://doi.org/10.1016/j.indcrop.2021.113295

Xiong, F., Liu, RX, Fan, XX, Zhang, M., She, Y., Cao, WQ, Chen, C., Ding, T.M., & Zhang, SY (2023). Bringing Green Organic Electrochemistry to Undergraduates: A Designed Comparison Organic Experiment of Bromination. Journal of Chemical Education, 100 (12), 4686–4695. https://doi.org/10.1021/acs.jchemed.3c00869

Zhang, M., Day, E. L., McFall-Boegeman, H., Petritis, S. J., & Cooper, M. M. (2023). Incorporation of green chemistry into undergraduate organic laboratory using cooperative project-based experiments and case studies. Green Chemistry Letters and Reviews, 16(1), 2183781. https://doi.org/10.1080/17518253.2023.2183781

Zhang, Y. (2017). Zhang, Y. (2017). Discussion on the development of green chemistry and chemical engineering. IOP Conference Series: Earth and Environmental Science, 94, p. 012136. https://doi.org/10.1088/1755-1315/94/1/012136

Downloads

Published

2024-12-30

How to Cite

Lestari, N. A., Sulistyowati, D., Dellatiani, Y., Irawan, N. Z. P., Fadhilah, A., & Muyassaroh, A. (2024). Implementation of green chemistry approaches in chemistry labs instruction: A systematic literature review. Jurnal Pendidikan Kimia, 16(3), 263 – 277. https://doi.org/10.24114/jpkim.v16i3.65184